ea0032p7 | Adrenal cortex | ECE2013
Penna-Martinez Marissa
, Schwartz Julia M.
, Shoghi Faroquhi
, Meyer Gesine
, Wolff Anette B.
, Hahner Stephanie
, Willenberg Holger
, Reisch Nicole
, Quinkler Marcus
, Seidl Christian
, Husebye Eystein
, Badenhoop Klaus
Autoimmune Addisons disease (AAD) results from the immune mediated selective destruction of adrenal steroid hormone-secreting cells. Autoantibodies (Abs) against 21-hydroxylase (21OH) are diagnostic present in 8590% newly diagnosed patients. Its genetic susceptibility is conferred by human leukocyte antigen (HLA) DQ2 and DQ8. In many patients autoimmunity extends forming the autoimmune polyglandular syndrome type 2 (APS-2). The aim of this study was to test, whethe...